drug acting on neuromuscular junction
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Pre-junctional blocker
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Post-junctional blocker (Non-depolarizing
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Post-junctional blocker (Depolarizing
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Anticholinesterase (Anti-ACHase) inhibitor
|
|
MOA:
1) Prevent Ach release 2) Inhibit Ach synthesis |
MOA:
1) Non-depolarizing: compete with Ach, inhibit nicotinic Rc |
MOA:
Act like Ach, bind to nicotinic Rc |
MOA:
Inhibit Anti-ACHase breaking down Ach |
|
Example:
Butolinum toxin Aminoglycoside |
Example:
d-tubocurarine |
Example:
Suxamethonium |
Example:
Neostigmine Edroponium |
|
↓ muscle contraction
|
Phase 1: slight muscle contrx
Phase 2: desensatization, complete paralysis |
↑ muscle contraction
|
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