NSAIDS Cheat Sheet

A Education › Biology cheat sheet in English by aina

List of nsaids medication

Medicine Pharmacology

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PRs

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MOA

Enzyme targets by NSAIDs

REMEMBER

COX-2
= C = K = Kidney
= 2 = B = Brain

COX-1 = 1 = Number 1 so good at affecting everything else

Chemical mediators of inflammation

extra information

Common NSAIDs

NOTES:
Cannot take other NSAIDs before taking aspirin because they may prevent aspirin action
COX-2 selective has less AE of GI
* Naproxane less CVS effect dt antithromboxane

REMEMBER:

"ABCDiN"
- Aspirin
- iBuprofen, Naproxen
- COX-2 selective
- Diclofenac

COX-2 Selective, remember "-coxib"
main: Celecoxib

Beneficial effects of inhibition PG synthesis

Analgesia

↓Bradykinin, 5-HT (serotonin)

Antipyretic

↓ IL-1, reset thermostat

Anti-inflammatory

↓ PGE2, PGI1

Antithrombotic

by aspirin at low dose (permanent acetylation, inhibit platelet activation)

Arteriosus (NSAIDs for closure of patent ductus arteriosus)

Adverse effect

nSAIDS

Allergy
Impaired
Renal function
Damage stomach wall (ulcer)

Contraindication

Bleeding

Avoid in patient:
-Anticoagulants
-Pregnancy 3rd trimester (premature close DA, risk bleeding)
Inhibit platelet cycloxygenase (COX), thereby blocking the formation of thromboxane A2 (TXA2) and impairing TXA2 dependent platelet aggregation

Asthma

Inhibition of COX pathway shifts the arachidonic acid metabolism to Lipoxygenase (LOX) pathway leading to increased leukotriene synthesis

Allergy

Stomach (Peptic ulcer, gastritis)

Mucosal damage by –
COX-1 inhibition: Reduced blood flow
Topical irritation: Epithelial damage
COX-2 inhibition: Leukocyte adherence
*Can prescribe PPI for gastro-protection

CVS event

angina, recent cardiac bypass usrgery, MI, any CV events

REMEMBER
CBARS

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