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Aciclovir: Guanine analogue prodrug.
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M.O.A: Phosphorylated to active triphosphate by virally encoded thymidine kinase after cellular uptake. Triphosphate interferes with viral DNA polymerase and inhibits DNA replication.
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Spectrum of activity: Herpes simplex (I & II), Varicella-Zoster viruses
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Indications: Treatment of Herpes simplex (I & II), Varicella-Zoster viruses. Prophylaxis of frequent recurrent episodes of herpes genitalis.
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Drug interactions: Increased nephrotoxicity with nephrotoxic agents such as aminoglycosides.
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Ganciclovir:
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Indications: Treatment of sight or life – threatening cytomegalovirus (CMV) infections.
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Drug interactions: Concomitant administration with Zidovudine, azathiopurine and antineoplastic agents due to haematologic toxicity.
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Adverse effects: Myelosuppression.
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Ribavirin:
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Indications: Treatment of chronic hepatitis C infection in combination with peg-interferons.
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Drug interactions: Increased nephrotoxicity with nephrotoxic agents such as aminoglycosides.
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M.O.A: Active metabolite of phosphate prodrug inhibits neuraminidases of influenza types A and B.
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Oseltamivir
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M.O.A: Active metabolite of phosphate prodrug inhibits neuraminidases of influenza types A and B.
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Indications: Treatment of influenza A and B
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Aciclovir
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Valaciclovir
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Ganciclovir
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Valganciclovir
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Amantadine
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Oseltamivir
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Zanamivir
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Entecavir
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Lamivudine
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emtricitabine
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tenofovir
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