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Ability of a material to elicit an appropriate biological response in a given application in the body.
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Placement of a material creates an interface that is not normally present.
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Interface = Not static, includes dynamic interactions
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Activity of interface depends on: location of material, duration in body, properties of material and health of host.
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Biomaterials are not biologically inhert:
There are no inhert materials. Interactions depend on the material, the host and forces/conditions placed on the material. Material affects the host and host affects the material.
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Dynamic Process:
Body may change due to aging/disease. Material may change due to corrosion/fatigue. Changes may alter conditions where initially an appropriate/desired biological response took place. Biological response to a material is an ongoing process.
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Interaction
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Location:
Important to it's overall biological response. Determines if material will be covered by soft or mineralized tissue, will it be external to oral epithelium or if it will communicate through epithelium and will the material be directly exposed to bone, tissues , blood and saliva or will there be a barrier (such as enamel or dentin).
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Duration:
More stringent tests for longer duration.
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Stress:
Stresses placed on material (physical, chemical, thermal or occlusal or reaction to salivary proteins) may react unfavourably.
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Performed outside an organism
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First screening test done in test tubes, cell culture dish, flask.
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Material is placed in direct/indirect contact with some biological organism.
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Advantages:
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> Fast
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> Inexpensive
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> Easily standardised
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> larger scale screening conditions can be tightly controlled to provide the highest quality of scientific rigor.
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Place a material into contact with an intact organism
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Distinct difference, exposure without regard to the material’s final use
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Advantage:Ability to allow an intact biological system to respond to a material.
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Material is placed in an environment, clinically relevant to the use of the material in clinical practice
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Humans ( clinical trial ) and Animals closely resembling humans
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Advantage: Gold standard
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1. Toxicity:
normally the first screening test.
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2. Inflammation:
second fundamental type of biological response resulting either from allergy/ toxicity, first infiltration of neutrophils, then monocytes and other lymphocytes.
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3. Allergic Reaction:
the most common to lay people. Type I- refers to an immediate atopic /anaphylatic reaction when an antigen reacts with mast cell/basophils. Type II- is a cytotoxic hypersensitivity reaction. Type III-immune-complex hypersensitivity reaction. Type IV -delayed or cell-mediated hypersensitivity. Type V - stimulating-antibody reaction. Type VI- anti- body dependent, cell mediated cytoxicity reaction.
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4. Mutagenicity:
results when the components of a material alter the base-pair sequences of DNA in cells.
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Local: Pulp of the tooth, periodontium, root apex, soft tissues ( buccal mucosa/tongue)
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Systemic: Ingestion, absorption in the gut, , inhaled vapor, release a the tooth apex, absorption through the o/mucosa. As well as, Systemic biological response depends on; duration and concentration of the exposure, excretion rate of the substance, site of exposure.
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Degradation process: The biological response to the corrosion products depends on the amount, composition, and form of these products as well as their location in the tissues.
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Surface characteristics: research has shown that for all dental materials , the surface is very different compared to the interior.
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Examples:
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Latex:(3 categories: irritant, allergic & type1 hypersensitivity reaction) In dentistry; rubber dam, gloves, bite blocks etc. Reactions to latex ; localized rashes, swelling to a more serious wheezing and anaphylaxis. Dermatitis of the hands (most common).
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Mercury&Amalgam: No data to show that mercury released from dental amalgam is harmful.
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Estrogenicity: Ability of a chemical to act as the hormone estrogen in the body The placement of composites has been questioned. Xenoestrogen bisphenol A ( BPA) synthetic starting point for all Bis-GMA composites fear is that the release of these substances might alter normal cellular development or maintenance if the BPA has estrogenic effects.
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NIckel: Common component of many dental alloys including those used for crowns, fixed partial dentures, removable partial dentures and some orthodontic appliances. Endodontic files Reactions are often subtle, resemble periodontal inflammation Occurs primarily outside the mouth
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