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- Smoke+ Fog
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1. Reducing fog (Coal combustion, SOx)
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2. Photochemical oxidant smog (Incomplete combustion)
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Major
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Minor
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Pregnancy
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10x Higher prob of lung cancer
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Cardiovascular disease
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impact on fetus weight
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Marasmus
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Kwashiorkor
|
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- Starving
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- Protein deficiency
|
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- Normal serum albumin level
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- Hypoalbuminemia
|
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- Loss of muscle
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- General edema
|
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Function
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Deficiency
|
|
- Vision
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- Night blindness
|
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- Differentiation of epithelial cells
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- Xerophthalamia
|
|
- Host resistance
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- Pulmonary infections
|
|
- Metabolic effects on retinoids
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- Stones
|
|
- Hyperkeratosis
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Toxicity
|
l
|
Storage
|
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1. Inhibit heme synthesis
|
l
|
Bone& Teeth >Blood >Soft tissue
|
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2.2 Interfere brain development& nerve transmission
|
l
|
|
|
Source
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Deficiency
|
|
- UV light
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1. Children: Rickets
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- Dietary source
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- Cartilage overgrowth
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Metabolism
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2. Adult: Osteomalacia
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1,25(OH)2D: Most active form
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- Uncalcified bone
|
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Functions
|
|
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- Ca, P intestinal absorption
|
|
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- PTH-dependent reabsorption
|
|
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- Steroid hormone
|
|
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- Synthesis of clotting factor VII, IX, X
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- Bleeding diathesis
|
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- NOT synthesized
|
Scurvy
|
|
- Metabolism of collagen& basic intracellular matrix
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- Bleeding tendency
|
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