Second group of drugs that treat benign prostatic hypertrophy, or BPH, is the alpha adrenergic reseptor antagonists
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Prototype Med
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tamsulosin (Flomax)
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Other Meds
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silodosin (Rapaflo)
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alfuzosin (Urixatral)
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terazosin (Hytrin)
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doxazosin (Cardura)
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Reduced ejaculate volume, ejaculation failure, retrograde ejaculation (tamsulosin and silodosin)
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Headache and dizziness
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Hypotension, fainting, (nonselective alpha blockers, not tamsulosin)
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Tell clients about the possibility of altered ejaculation.
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Monitor for headache.
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Treat with mild analgesic.
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Monitor blood pressure.
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Report changes in B/P and HR.
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Take orally once a day.
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Take at the same time each day, 30 min after the same meal (such as breakfast).
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Swallow the capsules whole; do not crush or chew them.
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Expect decreases in ejaculate volume and ejaculation failure.
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Report headache not relieved with an over-the-counter analgesic.
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Have blood pressure checked regularly.
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Rise slowly from a reclining or sitting position. Report dizziness or fainting.
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Do not engage in dangerous activities if dizziness occurs or tends to recur.
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Advise client this drug will need to be taken lifelong.
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Concurrent use of erectile dysfunction drugs such as sildenafil (Viagra)
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Females, children
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Renal impairment
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History of syncope
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Hypotension
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Drugs that lower blood pressure can increase hypotensive effects of nonselective alpha blockers.
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Erythromycin, itraconazole (Sporanox), nefazodone (Serzone), and HIV protease inhibitors increase levels of nonselective alpha blockers.
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Cimetidine (Tagamet) may worsen orthostatic hypotension.
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