Oral Anticholinergic
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Prototype Med
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Oxybutynin Chloride
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Other Med
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Ditropan
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Treatment of urinary urge incontinence caused by overactive bladder
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Treatment of neurogenic bladder
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Dry mouth
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Constipation
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Urinary retention
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Mydriasis (pupil dilation), dry eyes, blurred vision
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Headache
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Dizziness, drowsiness
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Fever, heat exhaustion
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Monitor for anticholinergic effects.
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Monitor bowel elimination patterns.
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Monitor urinary elimination patterns, especially in older adults.
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Recommend periodic eye examinations
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Monitor for headache
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Monitor for dizziness and somnolence.
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Advise clients to use caution in hot weather, as the drug suppresses sweating.
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Take orally (either short-acting syrup or tablets) two to four times a day.
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Take the extended-release (ER) tablets once a day.
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Swallow ER tablets whole; do not crush or chew them.
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Expect excretion of the insoluble shell of the ER tablets in stool.
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Apply the transdermal patch twice a week to dry and intact skin on the abdomen, hip, or buttocks.
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Rotate patch adhesion sites.
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Angle-closure glaucoma
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Myasthenia gravis
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Gastrointestinal obstruction/Genitourinary obstruction
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Active cardiac dysfunction
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Urinary tract infection/Liver or renal disease
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Hiatal hernia with reflux
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Hyperthyroidism/Hypertension
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Benign prostatic hypertrophy
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Autonomic hypertrophy
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Suck on hard candy/Sip water
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Increase fluid and fiber intake and activity levels
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Report any undesirable changes in urinary elimination (retention, infec- tion).
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Use over-the-counter lubricating eye drops.
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Obtain regular eye examinations (potential for glaucoma).
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Report headache not relieved by over-the-counter analgesics.
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Report dizziness or fainting.
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Do not engage in dangerous activities if dizziness occurs or tends to recur.
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Avoid becoming overheated.
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Seek medical attention for fever and signs of heat exhaustion (muscle cramps, dizziness, nausea, vomiting).
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CYP3A4 inhibitors (grapefruit juice, ketoconazole, erythromycin, itracon- azole [Sporanox], plus others) may increase toxicity.
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CYP3A4 inducers (phenytoin [Dilantin], rifampin [Rifadin], carbamaze- pine [Tegretol], plus others) decrease effectiveness.
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