Pharmacology cheat sheet all in one page
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Direct M-cholinoceptors
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Pilocarpine
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Direct N-cholinoceptors
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Cytitone (Nicotine)
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Both
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Carbachol (acetylcholine)
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Direct cholinoceptors
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Binds to + activates muscarinic/nicotinic receptors
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Indirect cholinoceptors
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Inhibits the action of acetylcholinesterase
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Muscarinic (M) cholinergic drugs
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Produced at postganglionic nerve endings
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Nicotinic (N) cholinergic drugs
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Produced by stimulants of all autonomic ganglia
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M-cholinoceptors
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Stimulate M-cholinoceptors in the exocrine glands and autonomic ganglia
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N-cholinoceptors
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Stimulates N-cholinoceptors in arch of aorta + the respiratory centre.
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Cholinomimetics
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Bradycardia
Vasodilator Decrease blood pressure Glaucoma |
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Cholinergic drugs
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Bone marrow suppression
dry mouth Fever |
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M-cholinomimetics
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Miosis + decrease intraocular pressure + spasm of the accommodation
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Drugs
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AntiNicotinics - ganglion blockers
AntiMuscaranics - tertiary amines (atropine, scopolamine) and quaternary amines (ipratropium, benztropine) |
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MOA
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Inhibition of cholinesterase enzyme which inhibits the breakdown of Ach
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Side effects
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mydriasis, sweating, bradycardia, diarrhea
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Contraindication
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Bronchial asthma
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Cholinergic drugs
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Bronchial asthma
Urinary obstruction |
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