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pyruvate dehydrogenase is always phosphorylated and thus inactive.
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Consequently, glucose is processed to lactate rather than acetyl CoA.
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This condition results in unremitting lactic acidosis—high blood levels of lactic acid.
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. In such an acidic environment, many tissues malfunction, most notably the central nervous system.
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Nausea,Vomiting,Abdominal pain,Anxiety...
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Pyruvate Dehydrogenase Links Glycolysis to the Citric Acid Cycle
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Oxidative decarboxylation, from pyruvate to acetyl CoA, Mt
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The Citric Acid Cycle Oxidizes Two-Carbon Units
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8 steps, 3 irreversible steps, 3 NADH, 1 FADH2, 1 ATP, 2 CO2
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Entry to the Citric Acid Cycle and Metabolism Through It Are Controlled
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PDH, isocitrate dehydrogenase, alpha-Ketoglutarate dehydrogenase
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The Citric Acid Cycle Is a Source of Biosynthetic Precursors
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Citrate, alpha-ketoglutarate, succinyl CoA, oxaloacetate
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